Sizing the treatable population
How many patients need this?
Far more than four thousand.
The funnel · true linear scale
Peripheral artery diseaseUS · prevalentAHA / Circulation 2023
CLTIprevalentAHA / Circulation 2023
CLTI + tissue lossthe CollateGene indicationGlobal Vascular Guidelines 2019
Treatable / yearincident, healableNEJM 2017 · Deng / Research 2025
Every bar drawn to true proportion, anchored at total US PAD (~12M).
The two numbers that matter · zoomed in
Treatable / yearincident, healable CLTINEJM 2017 · Deng / Research 2025
Amputation floorUS, per yearAHA PAD Collaborative · CMS
IQVIA modeledper yearIQVIA market model 2026
IQVIA modeled 4,700 — 45–65× fewer than the treatable population.
Linear scale, anchored at 300,000 — the top of the treatable range. The red bar is 4,700.
References
- Allison MA, Armstrong DG, et al. Health disparities in peripheral artery disease: a scientific statement from the American Heart Association. Circulation. 2023;148(3):286–296.
- Conte MS, Bradbury AW, Kolh P, et al. Global vascular guidelines on the management of chronic limb-threatening ischaemia. Eur J Vasc Endovasc Surg / J Vasc Surg. 2019.
- Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017;376(24):2367–2375.
- Deng L, Du C, … Armstrong DG, Mills JL, et al. Forecasting the global burden of peripheral artery disease from 2021 to 2050. Research. 2025;8:Article 0702.
- AHA PAD Collaborative Heat Map; CMS Medicare geographic-variation files. Approx. 150,000 US major amputations per year.
- IQVIA CollateGene market model, 2026. Modeled treatable population of 4,700 per year.